Adaptations in gut Bacteroidales facilitate stable co-existence with their lytic bacteriophages.

ABSTRACT:

Background

Bacteriophages (phages) and bacteria within the gut microbiome persist in long-term stable coexistence. These interactions are driven by eco-evolutionary dynamics, where bacteria employ a variety of mechanisms to evade phage infection, while phages rely on counterstrategies to overcome these defences. Among the most abundant phages in the gut are the crAss-like phages that infect members of the Bacteroidales, in particular Bacteroides. In this study, we explored some of the mechanisms enabling the co-existence of four phage-Bacteroidales host pairs in vitro using a multi-omics approach (transcriptomics, proteomics and metabolomics). These included three Bacteroides species paired with three crAss-like phages (Bacteroides intestinalis and ϕcrAs

SUBMITTER: Cortes-Martin A 

PROVIDER: S-EPMC11601342 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature