Semaglutide-induced weight loss improves mitochondrial energy efficiency in skeletal muscle.

ABSTRACT:

Objective

Glucagon-like peptide 1 receptor agonists (e.g. semaglutide) potently induce weight loss and thereby reducing obesity-related complications. However, weight regain occurs when treatment is discontinued. An increase in skeletal muscle oxidative phosphorylation (OXPHOS) efficiency upon diet-mediated weight loss has been described, which may contribute to reduced systemic energy expenditure and weight regain. We set out to determine the unknown effect of semaglutide on muscle OXPHOS efficiency.

Methods

C57BL/6J mice were fed a high-fat diet for 12 weeks before receiving semaglutide or vehicle for 1 or 3 weeks. The rate of ATP production and O₂ consumption were measured by a high-resolution respirometry and fluorometry to determine OXPHOS efficiency in skele

SUBMITTER: Choi RH 

PROVIDER: S-EPMC11601453 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature