Perforation of the host cell plasma membrane during <i>Toxoplasma gondii</i> invasion requires rhoptry exocytosis.

ABSTRACT: Toxoplasma gondii is an obligate intracellular parasite, and the delivery of effector proteins from the parasite into the host cell during invasion is critical for invasion itself and for parasite virulence. The effector proteins are released from specialized apical secretory organelles known as rhoptries. While much has been learned recently about the structure and composition of the rhoptry exocytic machinery and the function of individual rhoptry effector proteins that are exocytosed, virtually nothing is known about how the released proteins are translocated across the host cell plasma membrane. Previous electrophysiology experiments reported an unanticipated observation that invasion by T. gondii is preceded by a transient increase in host cell plasma membrane conductanc

SUBMITTER: Male F 

PROVIDER: S-EPMC11601479 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature