Inhibition of Cardiac p38 Highlights the Role of the Phosphoproteome in Heart Failure Progression.

ABSTRACT: Heart failure (HF) is a complex condition characterized by the inability of the heart to pump sufficient oxygen to the organs to meet their metabolic needs. Among the altered signal transduction pathways associated with HF pathogenesis, the p38 mitogen-activated protein kinase (p38 MAPK) pathway-activated in response to stress- has attracted considerable attention for its potential role in HF progression and cardiac hypertrophy. However, the exact mechanisms by which p38 MAPK influences HF remain unclear. Addressing knowledge gaps may provide insight on why p38 inhibition has yielded inconsistent outcomes in clinical trials. Here we investigate the effects of p38 MAPK inhibition via SB203580 on cardiac remodeling in a guinea pig model of HF and sudden cardiac death. Using a well-establishe

SUBMITTER: Sedighi S 

PROVIDER: S-EPMC11601511 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature