APOE Protects Against Severe Infection with <i>Mycobacterium tuberculosis</i> by Restraining Production of Neutrophil Extracellular Traps.

ABSTRACT: While neutrophils are the predominant cell type in the lungs of humans with active tuberculosis (TB), they are relatively scarce in the lungs of most strains of mice that are used to study the disease. However, similar to humans, neutrophils account for approximately 45% of CD45+ cells in the lungs of Apoe ^-/- mice on a high-cholesterol (HC) diet following infection with Mycobacterium tuberculosis (Mtb). We hypothesized that the susceptibility of Apoe ^-/- HC mice might arise from an unrestrained feed-forward loop in which production of neutrophil extracellular traps (NETs) stimulates production of type I interferons by pDCs which in turn leads to the recruitment and activation of more neutrophils, and demonstrated that depleting neutrophils, deple

SUBMITTER: Liu D 

PROVIDER: S-EPMC11601580 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature