Discovering plasticity rules that organize and maintain neural circuits.

ABSTRACT: Intrinsic dynamics within the brain can accelerate learning by providing a prior scaffolding for dynamics aligned with task objectives. Such intrinsic dynamics should self-organize and self-sustain in the face of fluctuating inputs and biological noise, including synaptic turnover and cell death. An example of such dynamics is the formation of sequences, a ubiquitous motif in neural activity. The sequence-generating circuit in zebra finch HVC provides a reliable timing scaffold for motor output in song and demonstrates a remarkable capacity for unsupervised recovery following perturbation. Inspired by HVC, we seek a local plasticity rule capable of organizing and maintaining sequence-generating dynamics despite continual network perturbations. We adopt a meta-learning approach introduced b

SUBMITTER: Bell D 

PROVIDER: S-EPMC11601609 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature