Quantitative mapping of cerebrovascular reactivity amplitude and delay with breath-hold BOLD fMRI when end-tidal CO₂ quality is low.

ABSTRACT: Cerebrovascular reactivity (CVR), the ability of cerebral blood vessels to dilate or constrict in response to a vasoactive stimulus, is a clinically useful measure of cerebrovascular health. CVR is often measured using a breath-hold task to modulate blood CO₂ levels during an fMRI scan. Measuring end-tidal CO₂ (P_ETCO₂) with a nasal cannula during the task allows CVR amplitude to be calculated in standard units (vascular response per unit change in CO₂, or %BOLD/mmHg) and CVR delay to be calculated in seconds. The use of standard units allows for normative CVR ranges to be established and for CVR comparisons to be made across subjects and scan sessions. Although breath holding can be successfully performed by diverse patient populations

SUBMITTER: Clements RG 

PROVIDER: S-EPMC11601616 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature