Multi-level transcriptional regulation of embryonic sex determination and dosage compensation by the X-signal element <i>sex-1</i>.

ABSTRACT: The C. elegans nuclear hormone receptor sex-1 is known to be an embryonic X-signal element that represses xol-1, the sex-switch gene that is the master regulator of sex determination and dosage compensation. Several prior studies on sex-1 function have suggested that sex-1 may have additional downstream roles beyond the regulation of xol-1 expression. In this study we characterize some of these additional roles of sex-1 in regulating the dual processes of sex determination and dosage compensation during embryogenesis. Our study reveals that sex-1 acts on many of the downstream targets of xol-1 in a xol-1-independent manner. Further analysis of these shared but independently regulated downstream targets uncovered that

SUBMITTER: Jash E 

PROVIDER: S-EPMC11601627 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature