Cortical effects of dopamine replacement account for clinical response variability in Parkinson's disease.

ABSTRACT: Individual variability in clinical response to dopaminergic replacement therapy (DRT) is a key barrier to efficacious treatment for patients with Parkinson's disease (PD). A better understanding of the neurobiological sources of such inter-individual differences is necessary to inform future clinical interventions and motivate translational research. One potential source of this variability is an unintended secondary activation of extra-nigrostriatal dopamine systems by DRT, particularly in the neocortex. In this study, we use magnetoencephalography data collected from patients with PD before and after DRT to map their individual cortical neurophysiological responses to dopaminergic pharmacotherapy. By combining these DRT response maps with normative atlases of cortical dopamine receptor a

SUBMITTER: Wiesman AI 

PROVIDER: S-EPMC11601674 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature