The Role of p16Ink4a as an Early Predictor of Physiological Decline during Natural Aging.

ABSTRACT: Cellular senescence is a prominent accomplice of aging. The expression of gene p16ink4a has been established as a biomarker of cellular senescence in humans and animal models. However, it has not been extensively studied in clinical settings in the context of natural aging and the development of age-related diseases. Here, we report the results of a natural aging study that provided an assessment of cellular senescence and a battery of measures of clinical status, quality of life (QOL), and physical performance in 250 community-dwelling participants across age continuum. This report focused on analyzing predictive relationships between cellular senescence and different clinical assessments. Our results suggest that clinical labs and QOL assessments produce distinct groupings of participant

SUBMITTER: Tang L 

PROVIDER: S-EPMC11601678 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature