Negative BOLD Responses Surpass Positive Responses in Task Specificity, Reflecting Neural Reconfigurations Better Than Functional Connectivity.

ABSTRACT:

Objective

To investigate whether the Negative BOLD Response (NBR) is more task-specific than the Positive BOLD Response (PBR) during cognitive tasks and to determine whether task-evoked activity reflects brain reconfigurations during different tasks better than functional connectivity.

Methods

Functional Magnetic Resonance Imaging (fMRI) data were collected from 214 participants under 50 years old (152 in Dataset 1 and 62 in Dataset 2) performing twelve cognitive tasks spanning vocabulary, speed of processing, fluid reasoning, and memory domains. Data analysis included subject-level and group-level analyses, focusing on comparing the spatial patterns and task specificity of NBR and PBR through similarity measures using Dice coefficients. Additionally, functional connectivity

SUBMITTER: Picha SG 

PROVIDER: S-EPMC11601682 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature