Cross-sectional, interventional, and causal investigation of insulin sensitivity using plasma proteomics in diverse populations.

ABSTRACT:

Background

We previously reported significant correlations between a direct measure of insulin sensitivity (IS) and blood levels of proteins measured using the Proximity Extension Assay (PEA) in two European cohorts. However, protein correlations with IS within non-European populations, in response to short-term interventions that improve IS, and any causal associations with IS have not yet been established.

Methods

We measured 1,470 proteins using the PEA in the plasma of 1,015 research participants at Stanford University who underwent one or more direct measures of IS. Association analyses were carried out with multivariable linear regression within and across Stanford subgroups and within each of the two European cohorts. Association statistics were also meta-analyzed aft

SUBMITTER: Kho PF 

PROVIDER: S-EPMC11601714 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature