Single cell long read whole genome sequencing reveals somatic transposon activity in human brain.

ABSTRACT: The advent of single cell DNA sequencing revealed astonishing dynamics of genomic variability, but failed at characterizing smaller to mid size variants that on the germline level have a profound impact. In this work we discover novel dynamics in three brains utilizing single cell long-read sequencing. This provides key insights into the dynamic of the genomes of individual cells and further highlights brain specific activity of transposable elements.

SUBMITTER: Izydorczyk MB 

PROVIDER: S-EPMC11601780 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature