Proof-of-Concept Validation of Noninvasive Detection of Cortical Spreading Depolarization with High Resolution Direct Current-Electroencephalography with Future Device Recommendations.

ABSTRACT:

Background/objective

Cortical spreading depolarization (SD) is increasingly recognized as a major contributor to secondary brain injury. Noninvasive SD monitoring would enable the institution of SD-based therapeutics. Our primary objective is to establish proof-of-concept validation that scalp DC-potentials can provide noninvasive SD detection by comparing scalp direct-current (DC)-shifts from a high-density electrode array to SDs detected by gold-standard electrocorticography (ECoG). Our secondary objective is to assess usability and artifact tolerance.

Methods

An 83×58 mm thermoplastic elastomer array with 29 6-mm diameter Ag/AgCl 1-cm spaced electrodes, the CerebroPatch^™ Proof-of-Concept Prototype, was adhesively placed on the forehead with an intervening elect

SUBMITTER: Brown BR 

PROVIDER: S-EPMC11601781 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature