Identification of a Resistance Exercise-Specific Signaling Pathway that Drives Skeletal Muscle Growth.

ABSTRACT: A human model of unilateral endurance versus resistance exercise, in conjunction with deep phosphoproteomic analyses, was used to identify exercise mode-specific phosphorylation events. Among the outcomes, a resistance exercise-specific cluster of events was identified, and a multitude of bioinformatic- and literature-based predictions suggested that this was mediated by prolonged activation of a pathway involving MKK3b/6, p38, MK2, and mTORC1. Follow-up studies in humans and mice provide consistent support for the predictions and also revealed that resistance exercise-induced signaling through MKK3b and the induction of protein synthesis are highly correlated events (R = 0.87). Moreover, genetic activation of MKK3b/6 in skeletal muscles was sufficient to induce signaling through the membe

SUBMITTER: Zhu WG 

PROVIDER: S-EPMC11601848 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature