Role of neutrophils in the pathogenesis of Post Kala-azar Dermal Leishmaniasis (PKDL).

ABSTRACT:

Background

Post Kala-azar Dermal Leishmaniasis (PKDL) is a dermal sequel of visceral leishmaniasis (VL), poses a significant threat to the success of ongoing kala-azar elimination program, due to its potential role in sustaining transmission cycles and complicating disease management strategies. In VL, neutrophils have been identified as the 'first line of defence', having multiple roles in disease pathogenesis, but their role in PKDL, if any, still remains elusive; presenting a critical gap in knowledge, and was the aim of this study.

Methodology/principal findings

In a cohort of PKDL patients, CD66b+ neutrophils were quantified in skin biopsies, followed by immunostaining of FFPE sections to identify activated neutrophils (CD66b+/CD64+) and degranulated (CD66b+/MPO+), alon

SUBMITTER: Roy M 

PROVIDER: S-EPMC11602034 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature