EGFR-mediated HSP70 phosphorylation facilitates PCNA association with chromatin and DNA replication.

ABSTRACT: Efficient DNA replication requires highly coordinated programs for the timely recruitment of protein complexes to DNA replication forks. Defects in this process result in replication stress, which in turn activates cell cycle checkpoints, suppresses cell proliferation and induces apoptosis. In response to persistent cell growth signals that speed up DNA replication processes, cells accelerate the recruitment of DNA replication proteins to avoid DNA replication stress. The mechanisms by which cell growth signals induce processes to facilitate the recruitment of DNA replication proteins onto the replication sites remain unclear. Here, we report that the epidermal growth factor receptor (EGFR) phosphorylates heat shock protein 70 (HSP70) for DNA replication. Such a modification promotes nucle

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11602123 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature