Intra-host genomic diversity and integration landscape of human tissue-resident DNA virome.

ABSTRACT: The viral intra-host genetic diversities and interactions with the human genome during decades of persistence remain poorly characterized. In this study, we analyzed the variability and integration sites of persisting viruses in nine organs from thirteen individuals who died suddenly from non-viral causes. The viruses studied included parvovirus B19, six herpesviruses, Merkel cell (MCPyV) and JC polyomaviruses, totaling 127 genomes. The viral sequences across organs were remarkably conserved within each individual, suggesting that persistence stems from single dominant strains. This indicates that intra-host viral evolution, thus far inferred primarily from immunocompromised patients, is likely overestimated in healthy subjects. Indeed, we detected increased viral subpopulations in two ind

SUBMITTER: Pyoria L 

PROVIDER: S-EPMC11602146 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature