Emergence of planar cell polarity from the interplay of local interactions and global gradients.

ABSTRACT: Planar cell polarity (PCP) - tissue-scale alignment of the direction of asymmetric localization of proteins at the cell-cell interface - is essential for embryonic development and physiological functions. Abnormalities in PCP can result in developmental imperfections, including neural tube closure defects and misaligned hair follicles. Decoding the mechanisms responsible for PCP establishment and maintenance remains a fundamental open question. While the roles of various molecules - broadly classified into 'global' and 'local' modules - have been well-studied, their necessity and sufficiency in explaining PCP and connecting their perturbations to experimentally observed patterns have not been examined. Here, we develop a minimal model that captures the proposed features of PCP establishmen

SUBMITTER: Singh D 

PROVIDER: S-EPMC11602187 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature