Reciprocal suppression between TGFβ signaling and TNF stimulation finetunes the macrophage inflammatory response.

ABSTRACT: Inflammation plays a crucial role in the development of various disease conditions or is closely associated with them. Inflammatory cytokines like TNF often engage in interactions with other cytokines and growth factors, including TGFβ, to orchestrate inflammatory process. Basal/endogenous TGFβ signaling is a universal presence, yet the precise way TNF communicates with TGFβ signaling to regulate inflammation and influence inflammatory levels in macrophages has remained elusive. To address this question, this study utilized genetic approaches and a combination of molecular and cellular methods, including conditional TGFβ receptor knockout mice, human cells, RNAseq, ATACseq and Cut & Run-seq. The results reveal that the TGFβ signaling functions as a vital homeostatic pathway, curtailing unc

SUBMITTER: Xia Y 

PROVIDER: S-EPMC11602219 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature