Bmal1 haploinsufficiency impairs fear memory and modulates neuroinflammation via the 5-HT2C receptor.

ABSTRACT:

Background

BMAL1, a key regulator of circadian rhythms, plays a multifaceted role in brain function. However, the complex interplay between BMAL1, memory, neuroinflammation, and neurotransmitter regulation remains poorly understood. To investigate these interactions, we conducted a study using BMAL1-haplodeficient mice (BMAL1^+/-).

Methods

We exposed BMAL1^+/- mice to behavioral assessments including cued fear conditioning, new objection recognition (NOR) test, and Y-maze test to evaluate BMAL1^+/- haplodeficiency impact on memory. Furthermore, biochemical changes were analyzed through western blotting, and ELISA to explore further the mechanism of BMAL1^+/- in memory, and neuroinflammation.

Results

We found that BMAL1 haploinsu

SUBMITTER: Li W 

PROVIDER: S-EPMC11602290 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature