Keratinocyte carcinomas in survivors of childhood cancer: A report from the childhood cancer survivor study.

ABSTRACT:

Background

Childhood cancer survivors (CCS) are at increased risk for keratinocyte carcinomas (KC) however, the long-term incidence of single and multiple KC is not well established.

Objective

Identify risk factors and quantify KC cumulative incidence and multiple-incidence burden in CCS.

Methods

KC were identified among Childhood Cancer Survivor Study participants, a cohort of 5-year cancer survivors diagnosed <21 years of age between 1970 and 1999 in North America. Cumulative incidence was estimated and multivariable models assessed relative rates of KC associated with survivor and treatment characteristics.

Results

Among 25,658 participants, 1446 developed 5363 KC (93.5% basal cell carcinoma, 6.7% squamous cell carcinoma; mean age 37.0 years (range 7.3-67.4)

SUBMITTER: Boull C 

PROVIDER: S-EPMC11602347 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature