Potential shared gene signatures and molecular mechanisms between recurrent pregnancy loss and ovarian cancer.

ABSTRACT:

Background

Ovarian cancer (OV) is the second most prevalent gynecological tumor. Recurrent pregnancy loss (RPL) refers to two or more spontaneous abortions. However, the molecular mechanisms underlying both OV and RPL remain poorly understood. This article focuses on the exploration of the common genetic characteristics of OV and RPL and their molecular mechanisms.

Methods

The 71 differentially expressed genes associated with RPL and 1427 genes associated with OV survival were analyzed, among which 7 common genes were both important in the pathogenesis of RPL and OV. Then stepAIC analysis was performed to simplify the model and decrease the number of genes, which yielded a final set of 5 prognostic genes with coefficients to construct a prognostic risk scoring system. Univar

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11602398 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature