Unbiased immunome characterisation correlates with COVID-19 mRNA vaccine failure in immunocompromised adults.

ABSTRACT:

Introduction

Coronavirus disease 2019 (COVID-19) affects the population unequally, with a greater impact on older and immunosuppressed people.

Methods

Hence, we performed a prospective experimental cohort study to characterise the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination in immune-compromised patients (older adults and oncohaematologic patients), compared with healthy counterparts, based on deep characterisation of the circulating immune cell subsets.

Results and discussion

While acquired humoral and cellular memory did not predict subsequent infection 18 months after full vaccination, spectral and computational cytometry revealed several subsets within the CD8⁺ T-cells, B-cells, natural killer (NK) cells, monocytes

SUBMITTER: H-Vazquez J 

PROVIDER: S-EPMC11602488 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature