A targeted proteomics screen reveals serum and synovial fluid proteomic signature in patients with gout.

ABSTRACT:

Objective

To characterize the inflammatory proteome in both serum and synovial fluid (SF) of patients with gout, in comparison to healthy controls and individuals with osteoarthritis (OA), by utilizing a high-quality, high-throughput proteomic analysis technique.

Methods

Using the Olink Target 48 Inflammation panel, we measured serum concentrations of 45 inflammatory proteins in gout, OA, and healthy controls. We analyzed protein levels in SF samples from gout and OA, performed ROC curve analyses to identify diagnostic biomarkers, evaluate efficacy, and set cut-off values. Additionally, A protein-protein interaction (PPI) network was used to study protein relationships and significance.

Results

We have delineated the proteomic landscape of gout and identified 20 highl

SUBMITTER: Huang Z 

PROVIDER: S-EPMC11602490 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature