Orientation-independent quantification of macromolecular proton fraction in tissues with suppression of residual dipolar coupling.

ABSTRACT: Quantitative magnetization transfer (MT) imaging enables noninvasive characterization of the macromolecular environment of tissues. However, recent work has highlighted that the quantification of MT parameters using saturation radiofrequency (RF) pulses exhibits orientation dependence in ordered tissue structures, potentially confounding its clinical applications. Notably, in tissues with ordered structures, such as articular cartilage and myelin, the residual dipolar coupling (RDC) effect can arise owing to incomplete averaging of dipolar-dipolar interactions of water protons. In this study, we demonstrated the confounding effect of RDC on quantitative MT imaging in ordered tissues can be suppressed by using an emerging technique known as macromolecular proton fraction mapping based on sp

SUBMITTER: Gao Z 

PROVIDER: S-EPMC11602536 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature