Transient impact of chronic social stress on effort-based reward motivation in non-food restricted mice: Involvement of corticosterone.

ABSTRACT: Chronic stress has been connected to a reduced effort and motivational deficits. To study effort-based motivation in rodents, operant conditioning is often employed. However, caloric restriction is typically imposed simultaneously. Since caloric restriction is a stressor in its own right, this procedure interferes with data interpretation. Here, we investigate whether chronic social defeat stress (CSD), lasting 10 consecutive days, would alter effort-based reward motivation in mice trained under ad libitum food conditions. Utilizing operant FED3 boxes in home cages, mice were trained within eight days to nose poke for palatable food. After training completion, operant memory was retained for at least 16 days, and mice demonstrated sustained effort, as assessed with a progressive rat

SUBMITTER: Evertse D 

PROVIDER: S-EPMC11602574 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature