MICheck: a web tool for fast checking of syntactic annotations of bacterial genomes.

ABSTRACT: The annotation of newly sequenced bacterial genomes begins with running several automatic analysis methods, with major emphasis on the identification of protein-coding genes. DNA sequences are heterogeneous in local nucleotide composition and this leads sometimes to sequences being annotated as authentic genes when they are not protein-coding genes or are true but uncharacterized protein-coding genes. This first annotation step is generally followed by an expert manual annotation of the predicted genes. The genomic data (sequence and annotations) organized in an appropriate databank file format is subsequently submitted to an entry point of the International Nucleotide Sequence Database. These procedures are inevitably subject to mistakes, and this can lead to unintentional syntactic annot

SUBMITTER: Cruveiller S 

PROVIDER: S-EPMC1160258 | biostudies-literature | 2005 Jul

REPOSITORIES: biostudies-literature