Simultaneous assessment of cerebral glucose and oxygen metabolism and perfusion in rats using interleaved deuterium (²H) and oxygen-17 (¹⁷O) MRS.

ABSTRACT: Cerebral glucose and oxygen metabolism and blood perfusion play key roles in neuroenergetics and oxidative phosphorylation to produce adenosine triphosphate (ATP) energy molecules in supporting cellular activity and brain function. Their impairments have been linked to numerous brain disorders. This study aimed to develop an in vivo magnetic resonance spectroscopy (MRS) method capable of simultaneously assessing and quantifying the major cerebral metabolic rates of glucose (CMR_Glc) and oxygen (CMRO₂) consumption, lactate formation (CMR_Lac), and tricarboxylic acid (TCA) cycle (V_TCA); cerebral blood flow (CBF); and oxygen extraction fraction (OEF) via a single dynamic MRS measurement using an interleaved deuterium (²H) and oxygen-17 (

SUBMITTER: Zhang G 

PROVIDER: S-EPMC11602644 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature