³¹P multi-echo MRSI with low B₁ ⁺ dual-band refocusing RF pulses.

ABSTRACT: ³¹P magnetic resonance spectroscopy (MRS) can spectrally resolve metabolites involved in phospholipid metabolism whose levels are altered in many cancers. Ultra-high field facilitates the detection of phosphomonoesters (PMEs) and phosphodiesters (PDEs) with increased SNR and spectral resolution. Utilizing multi-echo MR spectroscopic imaging (MRSI) further enhances SNR and enables T₂ information estimation per metabolite. To address the specific absorption rate (SAR) challenges associated with high-power demanding adiabatic or composite block pulses in multi-echo phosphorus imaging, we present a dual-band refocusing RF pulse designed for operation at B₁ amplitudes of 14.8 μT which holds potential for integration into multi-echo sequences. Phantom and in vivo

SUBMITTER: Shams Z 

PROVIDER: S-EPMC11602691 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature