NLRP3 activation maintains intestinal epithelial barrier and reduces liver injury in alcoholic liver disease mice.

ABSTRACT:

Background

Alcoholic liver disease (ALD) patients with bacterial infections usually exhibit high mortality rates. Infections frequently involve bacteria such as Vibrio vulnificus and Enterococcus faecalis. Nevertheless, the mechanisms predisposing ALD patients to bacterial infections and the role of the NLRP3 inflammasome in the intestinal epithelial barrier in ALD remain unclear.

Methods

We established ALD mice models of WT, Nlrp3^-/- and Gsdmd^-/- through chronic alcohol consumption feeding and acute alcohol induction. We compared alterations in gut microbiota, ileitis, and adhesion protein expression, to analyze the role and potential mechanism of NLRP3 in the early onset of ALD. Concurrently, we examined the changes in inflammation and liver damage in

SUBMITTER: Li SQ 

PROVIDER: S-EPMC11602754 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature