Development of metabolic signatures of plant-rich dietary patterns using plant-derived metabolites.

ABSTRACT:

Background

Diet is an important modifiable lifestyle factor for human health, and plant-rich dietary patterns are associated with lower risk of non-communicable diseases in numerous studies. However, objective assessment of plant-rich dietary exposure in nutritional epidemiology remains challenging.

Objectives

This study aimed to develop and evaluate metabolic signatures of the most widely used plant-rich dietary patterns using a targeted metabolomics method comprising 108 plant food metabolites.

Methods

A total of 218 healthy participants were included, aged 51.5 ± 17.7 years, with 24 h urine samples measured using ultra-high-performance liquid chromatography-mass spectrometry. The validation dataset employed three sample types to test the robustness of the signature

SUBMITTER: Li Y 

PROVIDER: S-EPMC11602792 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature