Synovial calprotectin in prosthetic joint infection. A systematic review and meta-analysis of the literature.

ABSTRACT:

Introduction

Calprotectin is a protein endowed with antimicrobial properties, rendering it a distinctive marker for infection. Two methods are currently available for the assay of calprotectin: the enzyme-linked immunosorbent assay (ELISA) and the lateral flow test (LFT). We aimed to assess the diagnostic accuracy of synovial fluid calprotectin and to compare the accuracy of the laboratory-based test and the qualitative assessment for the diagnosis of hip and knee prosthetic infection.

Materials and methods

We searched (from inception to November 2023) MEDLINE, Scopus, EMBASE, Web of Science, and Cochrane for studies on calprotectin in the diagnosis of periprosthetic joint infection (PJI). Sensitivity, specificity, positive and negative likelihood ratio (LR), and diagnostic

SUBMITTER: Festa E 

PROVIDER: S-EPMC11602794 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature