Dopamine D1-Like Receptor Stimulation Induces CREB, Arc, and BDNF Dynamic Changes in Differentiated SH-SY5Y Cells.

ABSTRACT: The dopamine D1-like receptor is a dopamine (DA) receptor regulating diverse brain functions. Once the dopamine D1-like receptor is activated, it induces activation of the Protein Kinase A (PKA) that phosphorylates the cAMP Response Element-Binding (CREB) transcription factor, which once active elicits the expression of the critical synaptic elements Activity-regulated cytoskeleton-associated (Arc) and the Brain-Derived Neurotrophic Factor (BDNF). The temporality and subcellular localization of proteins impact brain function. However, there is no information about the temporality of CREB activation and Arc and BDNF levels induced through dopamine D1-like receptor activation. In this study, we aimed to assess the specific effect of dopamine D1-like receptor activation on the temporality of

SUBMITTER: Rivera-Maya OB 

PROVIDER: S-EPMC11602804 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature