Transposable elements contribute to tissue-specific gene regulation in humans.

ABSTRACT:

Background

Transposable elements (TEs) contribute to approximately half of the human genome, and along with many other functions, they have been known to play a role in gene regulation in the genome. With TEs' active/repressed states varying across tissue and cell types, they have the potential to regulate gene expression in a tissue-specific manner.

Objective and methods

To provide a systematic analysis of TEs' contribution in tissue-specific gene regulation, we examined the regulatory elements and genes in association with TE-derived regulatory sequences in 14 human cell lines belonging to 10 different tissue types using the functional genomics data from the ENCODE project. Specifically, we separately analyzed regulatory regions identified by three different approaches (DN

SUBMITTER: Ali A 

PROVIDER: S-EPMC11602805 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature