Open-lung ventilation versus no ventilation during cardiopulmonary bypass in an innovative animal model of heart transplantation.

ABSTRACT: Open-lung ventilation during cardiopulmonary bypass (CPB) in patients undergoing heart transplantation (HTx) is a potential strategy to mitigate postoperative acute respiratory distress syndrome (ARDS). We utilized an ovine HTx model to investigate whether open-lung ventilation during CPB reduces postoperative lung damage and complications. Eighteen sheep from an ovine HTx model were included, with ventilatory interventions randomly assigned during CPB: the OPENVENT group received low tidal volume (V_T) of 3 mL/kg and positive end-expiratory pressure (PEEP) of 8 cm H₂0, while no ventilation was provided in the NOVENT group as per standard of care. The recipient sheep were monitored for 6 h post-surgery. The primary outcome was histological lung damage, scored at the en

SUBMITTER: Karnik V 

PROVIDER: S-EPMC11602927 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature