Efficacy and safety of antidepressants for pain in older adults: A systematic review and meta-analysis.

ABSTRACT:

Aims

In many countries, pain is the most common indication for use of antidepressants in older adults. We reviewed the evidence from randomized controlled trials on the efficacy and safety of antidepressants, compared to all alternatives for pain in older adults (aged ≥65 years).

Methods

Trials published from inception to 1 February 2024, were retrieved from 13 databases. Two independent reviewers extracted data on study and participant characteristics, primary efficacy (pain scores, converted to 0-100 scale) and harms. Estimates for efficacy were pooled using a random effects model and reported as difference in means and 95% CI. Quality of included trials was assessed using the Cochrane risk of bias tool.

Results

Fifteen studies (n = 1369 participants) met the inclus

SUBMITTER: Narayan SW 

PROVIDER: S-EPMC11602952 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature