AMH regulates a mosaic population of AMHR2-positive cells in the ovarian surface epithelium.

ABSTRACT: The function and homeostasis of the mammalian ovary depend on complex paracrine interactions between multiple cell types. Using primary mouse tissues and isolated cells, we showed in vitro that ovarian follicles secrete factor(s) that suppresses the growth of ovarian epithelial cells in culture. Most of the growth suppressive activity was accounted for by Anti-Mullerian Hormone/Mullerian Inhibitory Substance (AMH/MIS) secreted by granulosa cells of the follicles, as determined by immune depletion experiments. Additionally, conditioned medium from granulosa cells from wild-type control, but not AMH knockout, suppressed epithelial cell growth. Tracing of the AMH-regulated cells using AMHR2 (AMH receptor 2)-Cre:ROSA26 mutant mice indicated the presence of populations of AMHR2-positive epithel

SUBMITTER: Smith ER 

PROVIDER: S-EPMC11602974 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature