Essential roles of B cell subsets in the progression of MASLD and HCC.

ABSTRACT:

Background & aims

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death. Metabolic dysfunction-associated steatotic liver disease (MASLD) is a significant cause of HCC. Current treatment options for HCC are very limited. Recent evidence highlights B cells as key drivers in MASLD progression toward HCC. However, it remains unclear whether multiple B cell populations or a distinct B cell subset regulates inflammatory responses during liver disease progression. The scope of this study was to define protumorigenic B cell subsets in MASLD and HCC.

Methods

Multicolor flow cytometry, immunohistochemistry, and immunofluorescence analyses were performed to investigate B cell populations locally (in liver tissue) and systemically (in the blood) in mice with

SUBMITTER: Petriv N 

PROVIDER: S-EPMC11602976 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature