Physical inactivity exacerbates pathologic inflammatory signalling at the single cell level in patients with systemic lupus.

ABSTRACT:

Background

Physical activity is an adjunctive therapy that improves symptoms in people living with systemic lupus erythematosus (SLE), yet the mechanisms underlying this benefit remain unclear.

Methods

We carried out a cohort study of 123 patients with SLE enrolled in the California Lupus Epidemiology Study (CLUES). The primary predictor variable was self-reported physical activity, which was measured using a previously validated instrument. We analyzed peripheral blood mononuclear cell (PBMC) single-cell RNA sequencing (scRNA-seq) data available from the cohort. From the scRNA-seq data, we compared immune cell frequencies, cell-specific gene expression, biological signalling pathways, and upstream cytokine activation states between physically active and inactive patients, a

SUBMITTER: Patterson SL 

PROVIDER: S-EPMC11603005 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature