Detection of enoxaparin and argatroban by use of the novel viscoelastic coagulometer ClotPro.

ABSTRACT: Owing to the simultaneous increase in the risk of thrombosis and bleeding in critically ill patients, point-of-care-available diagnostic tests to guide parenteral anticoagulation are warranted. We evaluated the detection of enoxaparin and argatroban, two commonly used parenteral anticoagulants, using the novel ClotPro viscoelastic coagulometer. For this experimental in vitro study at a tertiary care academic center, blood samples were drawn from twelve (six female, six male) healthy volunteers without intake of antithrombotic medication and no history of hemostatic disorders. Blood samples were spiked with enoxaparin (IU.ml^- 1) and argatroban (µg.ml^- 1) at increasing concentrations ranging from 0 to 1. The ClotPro Russell's viper venom (RVV)-test and the ClotPro ecari

SUBMITTER: Gratz J 

PROVIDER: S-EPMC11603016 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature