Photoacoustic polydopamine-indocyanine green (PDA-ICG) nanoprobe for detection of senescent cells.

ABSTRACT: Cellular senescence is considered an important tumour suppression mechanism in response to damage and oncogenic stress in early lesions. However, when senescent cells are not immune-cleared and persist in the tumour microenvironment, they can drive a variety of tumour-promoting activities, including cancer initiation, progression, and metastasis. Additionally, there is compelling evidence demonstrating a direct connection between chemo(radio)therapy-induced senescence and the development of drug resistance and cancer recurrence. Therefore, detection of senescent cells in tissues holds great promise for predicting cancer occurrence earlier, assessing tumour progression, aiding patient stratification and prognosis, and informing about the efficacy of potential senotherapies. However, effecti

SUBMITTER: Hartono M 

PROVIDER: S-EPMC11603024 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature