Exploration of drug repurposing for Mpox outbreaks targeting gene signatures and host-pathogen interactions.

ABSTRACT: Monkeypox (Mpox) is a growing public health concern, with complex interactions within host systems contributing to its impact. This study employs multi-omics approaches to uncover therapeutic targets and potential drug repurposing opportunities to better understand Mpox's molecular pathogenesis. We developed an in silico host-pathogen interaction (HPI) network and applied weighted gene co-expression network analysis (WGCNA) to explore interactions between Mpox and host proteins. Subtype-specific host-pathogen protein-protein interaction networks were constructed, and key modules from the HPI and WGCNA were integrated to identify significant host proteins. To predict upstream signaling pathways and transcription factors, we used eXpression2Kinases and ChIP-X Enrichment Analysis. The multi-S

SUBMITTER: Imani S 

PROVIDER: S-EPMC11603026 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature