Systemic biological mechanisms underpin poor post-discharge growth among severely wasted children with HIV.

ABSTRACT: In sub-Saharan Africa, children with severe malnutrition (SM) and HIV have substantially worse outcomes than children with SM alone, facing higher mortality risk and impaired nutritional recovery post-hospitalisation. Biological mechanisms underpinning this risk remain incompletely understood. This case-control study nested within the CHAIN cohort in Kenya, Uganda, Malawi, and Burkina Faso examined effect of HIV on six months post-discharge growth among children with SM and those at risk of malnutrition, assessed proteomic signatures associated with HIV in these children, and investigated how these systemic processes impact post-discharge growth in children with SM. Using SomaScan^TM assay, 7335 human plasma proteins were quantified. Linear mixed models identified HIV-associated

SUBMITTER: Mudibo EO 

PROVIDER: S-EPMC11603168 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature