Deep Crotonylproteomics Analysis of High-Altitude Exposure Hearts in Mice.

ABSTRACT: The potential molecular mechanisms of short-term adaptation and long-term structural deteriorations in the cardiac structure in response to high altitude remain not fully understood. This study aims to investigate changes in the crotonylproteome in the hearts of mice exposed to high altitude at different time points. The hearts were obtained from mice living at the lowland and 3, 10, and 30 days after arriving at a plateau. Crotonyllysolylated proteins were subsequently comprehensively evaluated. Among the identified 13,731 crotonyllysine sites, 11,140 were quantified. Furthermore, 1247 differentially expressed crotonyllysine sites on 764 proteins in 46 pathways were analyzed, and the results showed that the abundance of crotonylation increased with the increase of exposure time to altitud

SUBMITTER: Yue T 

PROVIDER: S-EPMC11603239 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature