Exploring molecular mechanisms of postoperative delirium through multi-omics strategies in plasma exosomes.

ABSTRACT: Currently, the diagnosis of delirium is solely based on clinical observation, lacking objective diagnostic tools, and the regulatory networks and pathological mechanisms behind it are not yet fully understood. Exosomes have garnered considerable interest as potential biomarkers for a variety of illnesses. This research aimed to delineate both the proteomic and metabolomic landscapes inherent to exosomes, assessing their diagnostic utility in postoperative delirium (POD) and understanding the underlying pathophysiological frameworks. Integrated analyses of proteomics and metabolomics were conducted on exosomes derived from plasma of individuals from both the non-postoperative delirium (NPOD) control group and the POD group. Subsequently, the study utilized the Connectivity Map (CMap) method

SUBMITTER: Yan F 

PROVIDER: S-EPMC11603267 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature