Elastin-like Recombinamers as a Biotechnological Platform for the Development of Cytokine-Functionalized Materials.

ABSTRACT: Oncostatin M (OSM) and leukemia inhibitory factor (LIF) are pleiotropic cytokines from the interkeukine-6 family, associated with several disorders, and present significant potential in biomedicine. However, their therapeutic use is highly constrained by factors such as short circulating half-life and narrow therapeutic window. The conjugation of cytokines with elastin-like recombinamers (ELR) holds the potential to circumvent these limitations due to the ability of self-assembling upon a thermal stimulus, remarkable biocompatibility, and ease of processing. In this work, we report on the development of genetically engineered hybrid ELR conjugates by fusing the DNA sequences coding for murine/human OSM and LIF into the C-terminus of an ELR. The resulting hybrid fusion proteins demonstrated

SUBMITTER: Goncalves A 

PROVIDER: S-EPMC11603303 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature