Synthesis of a multivalent α-1,2-mannobiose ligand for targeting C-type lectins.

ABSTRACT: The importance of lectins in biological processes such as pathogen recognition, cell adhesion, and cell recognition is well documented. C-Type lectins, which require calcium for binding, play an important role in the innate immune response by engaging carbohydrates presented as part of the human and pathogen glycocalyx. For example, lectins such as MBL, Dectin-2, langerin and DC-SIGN selectively recognize mannose rich (high-mannose) structures presented as part of the glycocalyx. One common sugar binding motif that is recognized by these lectins on the pathogen glycocalyx is α-1,2-mannobiose, a disaccharide that consists of two mannose units connected via a α-1,2-linkage. To study the binding of these motifs in different contexts, synthetic replicas of α-1,2-mannobiose that can be p

SUBMITTER: Langer J 

PROVIDER: S-EPMC11603336 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature