"Quality over quantity:" smaller, targeted lesions optimize quality of life outcomes after MR-guided focused ultrasound thalamotomy for essential tremor.

ABSTRACT:

Introduction

MRI-guided focused ultrasound (MRgFUS) thalamotomy of the nucleus ventralis intermedius (VIM) has emerged as a powerful and safe treatment modality for refractory essential tremor. While the efficacy of this technique has been extensively described, much remains unclear about how to optimize MRgFUS for patient quality of life (QoL), which may depend as much on a patient's adverse effect profile as on the magnitude of tremor suppression. Diffusion tensor imaging (DTI) has been used to help guide targeting strategies but can pose certain challenges for scalability.

Methods

In this study, we propose the use of a simplified patient-reported change in QoL assessment to create an unbiased representation of a patient's perception of overall benefit. Further, we propose

SUBMITTER: Buch VP 

PROVIDER: S-EPMC11603361 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature