Decelerated skin aging effect of rubber (Hevea brasiliensis) seed oil in cell culture assays.

ABSTRACT: Rubber seeds, the abundant by-products of rubber tree (Hevea brasiliensis), have been studied for sustainable utilization. Nevertheless, there is no information available regarding activity against skin aging. The study aimed to prepare rubber seed oil (RSO) and evaluate fatty acid compositions by gas chromatography - mass spectrometry (GC/MS), linamarin contamination by ultra-high performance liquid chromatography - tandem mass spectrometry (UPLC-MS/MS). Additionally, cytotoxicity assay and anti-skin aging activities, including cell proliferating stimulation, cellular antioxidant, collagen stimulation, and matrix metalloproteinase-2 (MMP-2) inhibition, were analyzed in immortalized human skin keratinocytes (HaCaT cells) and human dermal fibroblasts. RSO was pale-yellow oily liquid with an

SUBMITTER: Chaikul P 

PROVIDER: S-EPMC11603368 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature